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I'm testing some frost poison calculations (6x27) against Flame Atronachs and my poison+bow damage (frostwyrm+iron arrow at 1/6 damage max difficulty) should surpass the creature's 150 health, but it falls far short (about 25 points short). I have played around with the numbers and the only things that seems to make sense is if the stated 50% weakness to frost is not in effect, or if the creature is able to reflect 15% of poison damage.

Any ideas?

Could poison damage be affected by spell efficiency?

Don't Daedra have a poison resistance?

Just went to the Flame Atronach page and found this: 100% resist poison (immune to poison)

Well then that explains it. A message should pop up in that case, like "Flame Atronach resisted poison effect".

Sorry, I edited down a longer post that had the number breakdown in it. I was using the 25% weakness to poison spell with 100% spell efficiency. I calculated that, the 1/6 damage for max difficulty, and the flamer's 50% weakness to frost for both Frostwyrm and the poison.

What type of poison are you using? I am pretty sure even a poison with frost damage will have to go through the formula first. I'll need to check but I think that whaf might be happening is that your damage from the poison is being reduced, and only then multiplied by the weakness.

edit: right, so here are the resistance and weakness equations:
So assuming that you are using frost damage on your poison as well, the following should apply:
That's pretty easy, it's 85. So you have an Atronach with an 85% resistance to poison. The wiki doesn't have that many example equations, but I'm pretty sure it's this:
I'm assuming the poison damage gets multiplied with the resistance because there isn't a total weakness present but I could be wrong. Either way, I don't think you'll be getting that much damage from poison.